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Drew Peterson heads to trial in third wife's death

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Brodsky said he has three pathologists ready to testify that Savio's death was, as originally determined, an accident.

The defense is bound to use the disputed findings to put forth its own theory about why Peterson was charged – "because of heat from law enforcement," Geragos said.

If there is any physical evidence linking Peterson to the crime, prosecutors have not said what it is. Instead, the case they present to the jury is expected to be largely, if not totally, circumstantial.

Will County State's Attorney James Glasgow, who famously said after Peterson's arrest in 2009 that Savio would speak "from the grave," is expected to call witnesses to testify about what Savio and Stacy Peterson told them.

Already, people have testified at a previous hearing that Savio described episodes in which Peterson held a knife to her throat and told her there was nothing she could do to protect herself from him.

Even without physical evidence, jurors can convict suspects on circumstantial cases. And they do so often.

"The jury is going to look at this like a web, and good circumstantial cases put the defendant in the middle of that web," said David Erickson, a former state appellate judge who teaches law at Chicago Kent College of Law.

The biggest question is whether Peterson will take the stand. Brodsky will not say. In many cases, attorneys reserve that decision until after prosecutors complete their evidence.

But Erickson suggested that Peterson might have to testify.

Good circumstantial cases "force defendants to take the stand," he said. "You are in the middle of that web, and you've got to come up with an alternate explanation of how you got there."

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