CHICAGO – The Cubs got their 100th loss of the season when Lucas Harrell threw six shutout innings to lead the Houston Astros to a 3-0 win Monday night.

Four Houston pitchers combined on a two-hitter, and Fernando Martinez homered for the third consecutive game. The Astros avoided their franchise-record 107th loss in the opener of their final series in the National League before they move to the American League next season.

The Cubs lost 100 games in a season for the first time since 1966 and were shut out for the 14th time this season. The Cubs have lost more than 99 games twice, setting the franchise record of 103 losses in 1962 and 1966. The Cubs have dropped 12 of their past 14.