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Company shares closed 2012 at $48.35, a 19 percent gain from the end of 2011. That topped the Standard and Poor's 500 index increase of about 13 percent. The stock has already climbed 7 percent in 2013 and hit a 52-week high price of $52.73 in late January.

CVS Caremark ranks 18th on the 2012 Fortune 500 list of biggest U.S. companies based on annual revenue. The company runs the second-largest chain of drugstores in the U.S. after Walgreen, and its Caremark unit is one of the nation's largest PBMs. CVS Caremark operates more than 7,400 drugstores.

Analysts who cover the company expect, on average, earnings of $1.10 per share on $31.14 billion in revenue.

CVS Caremark's net income climbed 4 percent, to $1.06 billion, or 81 cents per share, in the final quarter of 2011. Revenue jumped 15 percent to $28.32 billion, helped by a 32 percent increase in revenue from its PBM business.

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